Complement dysregulation in glomerulonephritis
نویسندگان
چکیده
منابع مشابه
Hereditary and acquired complement dysregulation in membranoproliferative glomerulonephritis.
Membranoproliferative glomerulonephritis (MPGN) is a chronic progressive renal disease that is diagnosed on the basis of renal histological features. Several MPGN subtypes have been defined by the localization and composition of glomerular deposits (electron dense, Ig and C3). MPGN II or dense deposit disease (DDD) which is defined by the occurrence of electron dense deposits within the lamina ...
متن کاملDifferent types of glomerulonephritis associated with the dysregulation of the complement alternative pathway in 2 brothers
RATIONALE C3 glomerulonephritis (C3GN) and complement-mediated hemolytic uremic syndrome (HUS) both result from the abnormal regulation of the complement system. A significant number of patients with C3GN or complement-mediated HUS have mutations of more than 1 complement protein. This discovery has had a major impact on identifying the underlying cause of familial C3GN or complement-mediated H...
متن کاملComplement and glomerulonephritis: new insights.
PURPOSE OF REVIEW The last few years have seen a huge increase in our understanding of the role of the complement system and its regulation in glomerular disease. Our aim is to summarize the most important advances in this field. RECENT FINDINGS The role of complement in systemic lupus erythematosus continues to be elucidated. Classical pathway components protect from the development of autoi...
متن کاملNormal complement in early poststreptococcal glomerulonephritis.
Patients with acute poststreptococcal glomerulonephritis are usually found to have reduced serum concentrations of the third component of complement (C3), properdin, and total haemolytic complement (CH50).' We report here a unique variation of this pattern. A previously healthy 72-year-old boy was admitted to hospital after one day of macroscopic haematuria. Blood pressure was 110/80 mm Hg. Uri...
متن کاملGlomerular complement components in human glomerulonephritis.
154 of 255 individual human renal biopsies studied by immunofluorescence contained varying combinations of immunoglobulins (Ig), complement (C) components C1q, C3, C4, C5, C6, C8, C3 proactivator (C3PA), and/or properdin. 10 patients had linear deposits of Ig in glomeruli characteristic of antiglomerular basement membrane (GBM) antibodies; nine patients had C3 deposits (minimal in three) with g...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Seminars in Immunology
سال: 2019
ISSN: 1044-5323
DOI: 10.1016/j.smim.2019.101331